Elevated Monoamine Oxidase-A Distribution Volume in Borderline Personality Disorder Is Associated With Severity Across Mood Symptoms, Suicidality, and Cognition
Identifieur interne : 000A71 ( Main/Exploration ); précédent : 000A70; suivant : 000A72Elevated Monoamine Oxidase-A Distribution Volume in Borderline Personality Disorder Is Associated With Severity Across Mood Symptoms, Suicidality, and Cognition
Auteurs : Nathan J. Kolla ; Lina Chiuccariello ; Alan A. Wilson ; Sylvain Houle ; Paul Links ; R. Michael Bagby ; Shelley Mcmain ; Charis Kellow ; Jalpa Patel ; Paraskevi V. Rekkas ; Suvercha Pasricha ; Jeffrey H. MeyerSource :
- Biological psychiatry [ 0006-3223 ] ; 2014.
Abstract
Monoamine oxidase-A (MAO-A) is a treatment target in neurodegenerative illness and mood disorders that increases oxidative stress and predisposition toward apoptosis. Increased MAO-A levels in prefrontal cortex (PFC) and anterior cingulate cortex (ACC) occur in rodent models of depressive behavior and human studies of depressed moods. Extreme dysphoria is common in borderline personality disorder (BPD), especially when severe, and the molecular underpinnings of severe BPD are largely unknown. We hypothesized that MAO-A levels in PFC and ACC would be highest in severe BPD and would correlate with symptom magnitude.
[11C] Harmine positron emission tomography measured MAO-A total distribution volume (MAO-A VT), an index of MAO-A density, in severe BPD subjects (
Severe BPD was associated with greater PFC and ACC MAO-A VT compared with moderate BPD, MDE, and healthy control subjects (multivariate analysis of variance group effect:
These results suggest that elevated MAO-A VT is associated with multiple indicators of BPD severity, including BPD symptomatology, mood symptoms, suicidality, and neurocognitive impairment.
Url:
DOI: 10.1016/j.biopsych.2014.11.024
PubMed: 25698585
PubMed Central: 4942262
Affiliations:
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Wilson</name></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name></author><author><name sortKey="Links, Paul" sort="Links, Paul" uniqKey="Links P" first="Paul" last="Links">Paul Links</name></author><author><name sortKey="Bagby, R Michael" sort="Bagby, R Michael" uniqKey="Bagby R" first="R. Michael" last="Bagby">R. Michael Bagby</name></author><author><name sortKey="Mcmain, Shelley" sort="Mcmain, Shelley" uniqKey="Mcmain S" first="Shelley" last="Mcmain">Shelley Mcmain</name></author><author><name sortKey="Kellow, Charis" sort="Kellow, Charis" uniqKey="Kellow C" first="Charis" last="Kellow">Charis Kellow</name></author><author><name sortKey="Patel, Jalpa" sort="Patel, Jalpa" uniqKey="Patel J" first="Jalpa" last="Patel">Jalpa Patel</name></author><author><name sortKey="Rekkas, Paraskevi V" sort="Rekkas, Paraskevi V" uniqKey="Rekkas P" first="Paraskevi V." last="Rekkas">Paraskevi V. Rekkas</name></author><author><name sortKey="Pasricha, Suvercha" sort="Pasricha, Suvercha" uniqKey="Pasricha S" first="Suvercha" last="Pasricha">Suvercha Pasricha</name></author><author><name sortKey="Meyer, Jeffrey H" sort="Meyer, Jeffrey H" uniqKey="Meyer J" first="Jeffrey H." last="Meyer">Jeffrey H. Meyer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25698585</idno><idno type="pmc">4942262</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942262</idno><idno type="RBID">PMC:4942262</idno><idno type="doi">10.1016/j.biopsych.2014.11.024</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000702</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000702</idno><idno type="wicri:Area/Pmc/Curation">000702</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000702</idno><idno type="wicri:Area/Pmc/Checkpoint">000490</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000490</idno><idno type="wicri:Area/Ncbi/Merge">001A71</idno><idno type="wicri:Area/Ncbi/Curation">001A71</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A71</idno><idno type="wicri:doubleKey">0006-3223:2014:Kolla N:elevated:monoamine:oxidase</idno><idno type="wicri:Area/Main/Merge">000A75</idno><idno type="wicri:Area/Main/Curation">000A71</idno><idno type="wicri:Area/Main/Exploration">000A71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Elevated Monoamine Oxidase-A Distribution Volume in Borderline Personality Disorder Is Associated With Severity Across Mood Symptoms, Suicidality, and Cognition</title><author><name sortKey="Kolla, Nathan J" sort="Kolla, Nathan J" uniqKey="Kolla N" first="Nathan J." last="Kolla">Nathan J. Kolla</name></author><author><name sortKey="Chiuccariello, Lina" sort="Chiuccariello, Lina" uniqKey="Chiuccariello L" first="Lina" last="Chiuccariello">Lina Chiuccariello</name></author><author><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A." last="Wilson">Alan A. Wilson</name></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name></author><author><name sortKey="Links, Paul" sort="Links, Paul" uniqKey="Links P" first="Paul" last="Links">Paul Links</name></author><author><name sortKey="Bagby, R Michael" sort="Bagby, R Michael" uniqKey="Bagby R" first="R. Michael" last="Bagby">R. Michael Bagby</name></author><author><name sortKey="Mcmain, Shelley" sort="Mcmain, Shelley" uniqKey="Mcmain S" first="Shelley" last="Mcmain">Shelley Mcmain</name></author><author><name sortKey="Kellow, Charis" sort="Kellow, Charis" uniqKey="Kellow C" first="Charis" last="Kellow">Charis Kellow</name></author><author><name sortKey="Patel, Jalpa" sort="Patel, Jalpa" uniqKey="Patel J" first="Jalpa" last="Patel">Jalpa Patel</name></author><author><name sortKey="Rekkas, Paraskevi V" sort="Rekkas, Paraskevi V" uniqKey="Rekkas P" first="Paraskevi V." last="Rekkas">Paraskevi V. Rekkas</name></author><author><name sortKey="Pasricha, Suvercha" sort="Pasricha, Suvercha" uniqKey="Pasricha S" first="Suvercha" last="Pasricha">Suvercha Pasricha</name></author><author><name sortKey="Meyer, Jeffrey H" sort="Meyer, Jeffrey H" uniqKey="Meyer J" first="Jeffrey H." last="Meyer">Jeffrey H. Meyer</name></author></analytic><series><title level="j">Biological psychiatry</title><idno type="ISSN">0006-3223</idno><idno type="eISSN">1873-2402</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>BACKGROUND</title><p id="P1">Monoamine oxidase-A (MAO-A) is a treatment target in neurodegenerative illness and mood disorders that increases oxidative stress and predisposition toward apoptosis. Increased MAO-A levels in prefrontal cortex (PFC) and anterior cingulate cortex (ACC) occur in rodent models of depressive behavior and human studies of depressed moods. Extreme dysphoria is common in borderline personality disorder (BPD), especially when severe, and the molecular underpinnings of severe BPD are largely unknown. We hypothesized that MAO-A levels in PFC and ACC would be highest in severe BPD and would correlate with symptom magnitude.</p></sec><sec id="S2"><title>METHODS</title><p id="P2">[<sup>11</sup>C] Harmine positron emission tomography measured MAO-A total distribution volume (MAO-A V<sub>T</sub>), an index of MAO-A density, in severe BPD subjects (<italic>n</italic> = 14), moderate BPD subjects (<italic>n</italic> = 14), subjects with a major depressive episode (MDE) only (<italic>n</italic> = 14), and healthy control subjects (<italic>n</italic> = 14). All subjects were female.</p></sec><sec id="S3"><title>RESULTS</title><p id="P3">Severe BPD was associated with greater PFC and ACC MAO-A V<sub>T</sub> compared with moderate BPD, MDE, and healthy control subjects (multivariate analysis of variance group effect: <italic>F</italic><sub>6,102</sub> = 5.6, <italic>p</italic> < .001). In BPD, PFC and ACC MAO-A V<sub>T</sub> were positively correlated with mood symptoms (PFC: <italic>r</italic> = .52, <italic>p</italic> = .005; ACC: <italic>r</italic> = .53, <italic>p</italic> = .004) and suicidality (PFC: <italic>r</italic> = .40, <italic>p</italic> = .037; ACC: <italic>r</italic> = .38, <italic>p</italic> = .046), while hippocampus MAO-A V<sub>T</sub> was negatively correlated with verbal memory (<italic>r</italic> = −.44, <italic>p</italic> = .023).</p></sec><sec id="S4"><title>CONCLUSIONS</title><p id="P4">These results suggest that elevated MAO-A V<sub>T</sub> is associated with multiple indicators of BPD severity, including BPD symptomatology, mood symptoms, suicidality, and neurocognitive impairment.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bagby, R Michael" sort="Bagby, R Michael" uniqKey="Bagby R" first="R. Michael" last="Bagby">R. Michael Bagby</name><name sortKey="Chiuccariello, Lina" sort="Chiuccariello, Lina" uniqKey="Chiuccariello L" first="Lina" last="Chiuccariello">Lina Chiuccariello</name><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><name sortKey="Kellow, Charis" sort="Kellow, Charis" uniqKey="Kellow C" first="Charis" last="Kellow">Charis Kellow</name><name sortKey="Kolla, Nathan J" sort="Kolla, Nathan J" uniqKey="Kolla N" first="Nathan J." last="Kolla">Nathan J. Kolla</name><name sortKey="Links, Paul" sort="Links, Paul" uniqKey="Links P" first="Paul" last="Links">Paul Links</name><name sortKey="Mcmain, Shelley" sort="Mcmain, Shelley" uniqKey="Mcmain S" first="Shelley" last="Mcmain">Shelley Mcmain</name><name sortKey="Meyer, Jeffrey H" sort="Meyer, Jeffrey H" uniqKey="Meyer J" first="Jeffrey H." last="Meyer">Jeffrey H. Meyer</name><name sortKey="Pasricha, Suvercha" sort="Pasricha, Suvercha" uniqKey="Pasricha S" first="Suvercha" last="Pasricha">Suvercha Pasricha</name><name sortKey="Patel, Jalpa" sort="Patel, Jalpa" uniqKey="Patel J" first="Jalpa" last="Patel">Jalpa Patel</name><name sortKey="Rekkas, Paraskevi V" sort="Rekkas, Paraskevi V" uniqKey="Rekkas P" first="Paraskevi V." last="Rekkas">Paraskevi V. Rekkas</name><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A." last="Wilson">Alan A. Wilson</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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